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Structure of PDB 1sg0 Chain B

Receptor sequence >1sg0B (length=230) Species: 9606 (Homo sapiens) [Search protein sequence] AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRA TDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQ FPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGG TAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEER KGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ

3D structure PDB 1sg0 Crystal structure of quinone reductase 2 in complex with resveratrol Chain B Resolution 1.5 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) G149 Y155 N161 Catalytic site (residue number reindexed from 1) G149 Y155 N161 Enzyme Commision number 1.10.5.1: ribosyldihydronicotinamide dehydrogenase (quinone).

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 STL B W105 F106 N161 W105 F106 N161 MOAD: Kd=35nM BindingDB: IC50=960nM,Ki=88nM,Kd=54nM BS02 ZN B H173 H177 C222 H173 H177 C222 BS03 FAD B H11 S16 F17 N18 S20 L103 Y104 W105 F106 G149 Y155 E193 R200 H11 S16 F17 N18 S20 L103 Y104 W105 F106 G149 Y155 E193 R200 BS04 STL B F126 G174 F178 F126 G174 F178 MOAD: Kd=35nM BindingDB: IC50=960nM,Ki=88nM,Kd=54nM

Gene Ontology Molecular Function GO:0001512 dihydronicotinamide riboside quinone reductase activity GO:0003955 NAD(P)H dehydrogenase (quinone) activity GO:0005515 protein binding GO:0008270 zinc ion binding GO:0009055 electron transfer activity GO:0016491 oxidoreductase activity GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors GO:0031404 chloride ion binding GO:0042803 protein homodimerization activity GO:0046872 metal ion binding GO:0071949 FAD binding GO:1904408 melatonin binding GO:1905594 resveratrol binding

	Biological Process
GO:1901662	quinone catabolic process

	Cellular Component
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular exosome

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