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Structure of PDB 1htb Chain B

Receptor sequence >1htbB (length=374) Species: 9606 (Homo sapiens) [Search protein sequence] STAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDD HVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKC RVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYT VVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGL GGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPI QEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQN LSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVL PFEKINEGFDLLHSGKSICTVLTF

3D structure PDB 1htb X-ray structure of human beta3beta3 alcohol dehydrogenase. The contribution of ionic interactions to coenzyme binding. Chain B Resolution 2.4 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 C369 Catalytic site (residue number reindexed from 1) C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 C369 Enzyme Commision number 1.1.1.105: all-trans-retinol dehydrogenase (NAD(+)).

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 ZN B C97 C100 C103 C111 C97 C100 C103 C111 BS02 ZN B C46 H67 C174 C46 H67 C174 BS03 NAD B C46 R47 T48 H51 C174 T178 G201 V203 D223 K228 I269 R271 V292 G293 V294 V318 C46 R47 T48 H51 C174 T178 G201 V203 D223 K228 I269 R271 V292 G293 V294 V318 MOAD: Kd=670uM BS04 PYZ B T48 H67 F93 L116 C174 T48 H67 F93 L116 C174

Gene Ontology Molecular Function GO:0004022 alcohol dehydrogenase (NAD+) activity GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity GO:0005515 protein binding GO:0008270 zinc ion binding GO:0016491 oxidoreductase activity GO:0046872 metal ion binding

	Biological Process
GO:0001523	retinoid metabolic process
GO:0006629	lipid metabolic process
GO:0042572	retinol metabolic process
GO:0042573	retinoic acid metabolic process

	Cellular Component
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane

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