Structure of PDB 1h28 Chain B

Receptor sequence

>1h28B (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]

VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEE
YKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPE
VAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQP
ANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPE
SLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLL
NPPETLNL

3D structure

PDB

1h28 Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A

Chain

Resolution

2.8 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	M210 W217 E220 E224 G251 Q254 Y280 I281 T282 T285 Y286	M36 W43 E46 E50 G77 Q80 Y106 I107 T108 T111 Y112

Gene Ontology

	Molecular Function
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity

	Biological Process
GO:0044772	mitotic cell cycle phase transition

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1h28, PDBe:1h28, PDBj:1h28
PDBsum	1h28
PubMed	12501191
UniProt	P20248\|CCNA2_HUMAN Cyclin-A2 (Gene Name=CCNA2)

[Back to BioLiP]

zhanglab

zhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417