Structure of PDB 1gjb Chain B

Receptor sequence

>1gjbB (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]

IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLMSPCWVISATHCFID
YPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIAL
LKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKEASTDYLY
PEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGG
PLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTK

3D structure

PDB

1gjb Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets.

Chain

Resolution

1.9 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1)	H46 D97 Q195 G196 D197 S198 G199
Enzyme Commision number	3.4.21.73: u-plasminogen activator.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	N26 P114 Q119 T120 I121 C122 M207	N11 P113 Q118 T119 I120 C121 M210
BS02	130	B	H57 S190 C191 Q192 S195 V213 W215	H46 S193 C194 Q195 S198 V216 W218	MOAD: Ki=0.45uM PDBbind-CN: -logKd/Ki=6.35,Ki=0.45uM

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity

	Biological Process
GO:0006508	proteolysis

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1gjb, PDBe:1gjb, PDBj:1gjb
PDBsum	1gjb
PubMed	11731301
UniProt	P00749\|UROK_HUMAN Urokinase-type plasminogen activator (Gene Name=PLAU)

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