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Structure of PDB 1fby Chain B

Receptor sequence >1fbyB (length=212) Species: 9606 (Homo sapiens) [Search protein sequence] DMPVERILEAELAVEPDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDD QVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIF DRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKV YASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTP IDTFLMEMLEAP

3D structure PDB 1fby Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid. Chain B Resolution 2.25 Å 3D structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Enzyme Commision number ?

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 9CR B I1268 A1271 A1272 Q1275 F1313 R1316 L1326 A1327 V1342 C1432 I22 A25 A26 Q29 F67 R70 L80 A81 V96 C186 MOAD: Kd=1.5nM BindingDB: EC50=100nM,Ki=583nM,IC50=32nM,Kd=240nM

Gene Ontology Molecular Function GO:0003677 DNA binding GO:0003707 nuclear steroid receptor activity GO:0008270 zinc ion binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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