Structure of PDB 1e2p Chain B

Receptor sequence

>1e2pB (length=310) Species: 10298 (Human alphaherpesvirus 1) [Search protein sequence]

MPTLLRVYIDGPHGMGKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASE
TIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGG
EAGSPPALTLIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIPPTLP
GTNIVLGALPEDRHIDRLAKRLDLAMLAAIRRVYGLLANTVRYLQCGGSW
REDWGQLSGPQSNAGPRPHIGDTLFTLFRAPELLAPNGDLYNVFAWALDV
LAKRLRSMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPTICDL
ARTFAREMGE

3D structure

PDB

1e2p The Effect of Substrate Binding on the Conformation and Structural Stability of Herpes Simplex Virus Type 1 Thymidine Kinase

Chain

Resolution

2.5 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	K62 E83 D162 R163
Catalytic site (residue number reindexed from 1)	K17 E38 D113 R114
Enzyme Commision number	2.7.1.21: thymidine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CCV	B	Q125 M128 R163 A168 Y172	Q80 M83 R114 A119 Y123	MOAD: Ki=27uM

Gene Ontology

	Molecular Function
GO:0004797	thymidine kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006230	TMP biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1e2p, PDBe:1e2p, PDBj:1e2p
PDBsum	1e2p
PubMed	11266595
UniProt	P0DTH5\|KITH_HHV11 Thymidine kinase (Gene Name=TK)

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