Structure of PDB 1aer Chain B

Receptor sequence

>1aerB (length=195) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]

FLGDGGDVSFSTRGTQNWTVERLLQAHRQLEERGYVFVGYHGTFLEAAQS
IVFGGVRARSQDLDAIWRGFYIAGDPALAYGYAQDQEPDRGRIRNGALLR
VYVPRSSLPGFYRTSLTLAAPEAAGEVERLIGHPLPLRLDAITGPRLETI
LGWPLAERTVVIPSAIPTDPRNVGGDLDPSSIPDKEQAISALPDY

3D structure

PDB

1aer Crystal structure of the catalytic domain of Pseudomonas exotoxin A complexed with a nicotinamide adenine dinucleotide analog: implications for the activation process and for ADP ribosylation

Chain

Resolution

2.3 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	E553
Catalytic site (residue number reindexed from 1)	E148
Enzyme Commision number	2.4.2.36: NAD(+)--diphthamide ADP-ribosyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TIA	B	H440 G441 Y470 Y481 E553	H41 G42 Y71 Y82 E148
BS02	AMP	B	H440 T442 A446 I450 R456 R458 F469	H41 T43 A47 I51 R57 R59 F70

Gene Ontology

	Molecular Function
GO:0047286	NAD+-diphthamide ADP-ribosyltransferase activity

View graph for
Molecular Function

External links

PDB	RCSB:1aer, PDBe:1aer, PDBj:1aer
PDBsum	1aer
PubMed	8692916
UniProt	P11439\|TOXA_PSEAE Exotoxin A (Gene Name=eta)

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