Structure of PDB 8wm0 Chain A

Receptor sequence

>8wm0A (length=299) Species: 9606 (Homo sapiens) [Search protein sequence]

EIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGD
EEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAG
SVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLL
TENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYD
FKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKK
FQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTK

3D structure

PDB

8wm0 A Compact Reprogrammed Genetic Code for De Novo Discovery of Proteolytically Stable Thiopeptides.

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.11.1: non-specific serine/threonine protein kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	Y36 D61 E62 F188 H237 M239 L242	Y25 D50 E51 F177 H226 M228 L231
BS02	ADN	A	V31 G34 A52 Q157 L160	V20 G23 A41 Q146 L149

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:8wm0, PDBe:8wm0, PDBj:8wm0
PDBsum	8wm0
PubMed	38491946
UniProt	Q9UKE5\|TNIK_HUMAN TRAF2 and NCK-interacting protein kinase (Gene Name=TNIK)

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