BioLiP

Structure of PDB 8vz1 Chain A

Receptor sequence

>8vz1A (length=239) Species: 9606 (Homo sapiens) [Search protein sequence]

SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTSHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTFLTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQ
LLLILSHIRHMSNKGMEHLYSMKNVVPSYDLLLEMLDAH

3D structure

PDB

8vz1 Asymmetric allostery in estrogen receptor-alpha homodimers drives responses to the ensemble of estrogens in the hormonal milieu.

Chain

Resolution

1.82 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	A1AHS	A	M342 M343 L346 T347 E353 L387 M388 L391 V418 M421 I424 F425 G521 H524 V533	M38 M39 L42 T43 E49 L83 M84 L87 V114 M117 I120 F121 G215 H218 V225

External links

PDB	RCSB:8vz1, PDBe:8vz1, PDBj:8vz1
PDBsum	8vz1
PubMed	38830107
UniProt	P03372\|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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