Structure of PDB 8e4t Chain A

Receptor sequence

>8e4tA (length=268) Species: 81824 (Monosiga brevicollis) [Search protein sequence]

SKEPRELNREWLIVLSELGQGAFGIVYEASLSEPKAPEIQVAAKSLRKDA
MDNEREELLEEALVMAQMEHANVVGLIGVITKGRPIYVVLEHMRNGSLKD
YVMNKTCTPAQQVTWSRQVASGMAHIHSLGFIHRDLAARNVLLSASLTAK
VADFGLARESTDSRGGNVPVRWTAPEALEDNIFSEKSDVWAFGVLMYEVY
TKAAMPYTGWNNQRVWIEVTNGFRLPCPADCPLPVFKIMSMCWLHDRHER
PSFETLVKALAALETDSD

3D structure

PDB

8e4t Crystal structure of the kinase domain of a receptor tyrosine kinase from a choanoflagellate, Monosiga brevicollis.

Chain

Resolution

1.95 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.10.1: receptor protein-tyrosine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	STU	A	V1557 A1573 K1575 H1623 M1624 G1627 R1670 L1673	V26 A42 K44 H92 M93 G96 R139 L142
BS02	STU	A	G1701 G1702 V1706 N1748	G165 G166 V170 N212

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:8e4t, PDBe:8e4t, PDBj:8e4t
PDBsum	8e4t
PubMed	37310965
UniProt	A9VBW0

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