Structure of PDB 7u6m Chain A

Receptor sequence

>7u6mA (length=327) Species: 556 (Dickeya chrysanthemi) [Search protein sequence]

DDKLPNIVILATGGTIAGSAATGTQTTGYKIGALGVDTLINAVPEVKKLA
NVKGEQFSNMASQNMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEE
SAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGR
GVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRID
KLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGM
GAGQVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNP
AHARILLMLALTRTSDPKVIQEYFHTY

3D structure

PDB

7u6m In vivo stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia.

Chain

Resolution

1.75 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

3.5.1.1: asparaginase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ASP	A	T15 A61 S62 Q63 G94 T95 D96	T15 A61 S62 Q63 G94 T95 D96

Gene Ontology

	Molecular Function
GO:0004067	asparaginase activity
GO:0016787	hydrolase activity

	Biological Process
GO:0006520	amino acid metabolic process
GO:0006528	asparagine metabolic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7u6m, PDBe:7u6m, PDBj:7u6m
PDBsum	7u6m
PubMed	35979719
UniProt	P06608\|ASPG_DICCH L-asparaginase (Gene Name=ansB)

[Back to BioLiP]

zhanglab

zhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417