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Structure of PDB 7bt5 Chain A

Receptor sequence >7bt5A (length=482) Species: 5833 (Plasmodium falciparum) [Search protein sequence] VDPRLYFENRSKFIQDQKDKGINPYPHKFERTISIPEFIEKYKDLGNGEH LEDTILNITGRIMRVSAQKLRFFDLVGDGEKIQVLANYSFHNHEKGNFAE CYDKIRRGDIVGIVGFPGKSKKGELSIFPKETILLSACLHMLPMKYGLKD TEIRYRQRYLDLLINESSRHTFVTRTKIINFLRNFLNERGFFEVETPMMN LIANARPFITHHNDLDLDLYLRIATELPLKMLIVGGIDKVYEIGKVFRNE GIDNTHNPEFTSCEFYWAYADYNDLIKWSEDFFSQLVYHLFGTYKISYNK DGPENQPIEIDFTPPYPKVSIVEEIEKVTNTILEQPFDSNETIEKMINII KEHKIELPNPPTAAKLLDQLASHFIENKYNDKPFFIVEHPQIMSPLAKYH RTKPGLTERLEMFICGKEVLNAYTELNDPFKQKECFDSAFCTSLEYGLPP TGGLGLGIDRITMFLTNKNSIKDVILFPTMRP

3D structure PDB 7bt5 Inhibition of Plasmodium falciparum Lysyl-tRNA synthetase via an anaplastic lymphoma kinase inhibitor. Chain A Resolution 2.493 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) R330 E332 T337 H338 E500 N503 R559 Catalytic site (residue number reindexed from 1) R248 E250 T255 H256 E418 N421 R460 Enzyme Commision number 6.1.1.6: lysine--tRNA ligase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 LYS A E308 E346 Y505 E507 G554 E226 E264 Y423 E425 G455 BS02 F6O A R330 E332 H338 N339 P340 F342 E500 G554 G556 R559 R248 E250 H256 N257 P258 F260 E418 G455 G457 R460 MOAD: Kd=239nM

Gene Ontology Molecular Function GO:0000166 nucleotide binding GO:0003676 nucleic acid binding GO:0004812 aminoacyl-tRNA ligase activity GO:0004824 lysine-tRNA ligase activity GO:0005524 ATP binding

	Biological Process
GO:0006418	tRNA aminoacylation for protein translation
GO:0006430	lysyl-tRNA aminoacylation

	Cellular Component
GO:0005737	cytoplasm

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