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BioLiP

Structure of PDB 6udi Chain A

Receptor sequence
>6udiA (length=155) Species: 9606 (Homo sapiens) [Search protein sequence]
DELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQ
RNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFG
AFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV
EDLEG
3D structure
PDB6udi Discovery and in Vivo Evaluation of Macrocyclic Mcl-1 Inhibitors Featuring an alpha-Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere.
ChainA
Resolution1.94 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Q4S A H224 A227 F228 V249 M250 V253 R263 T266 L267 F270 I294 H53 A56 F57 V78 M79 V82 R92 T95 L96 F99 I123 MOAD: ic50=0.3nM
PDBbind-CN: -logKd/Ki=10.00,Ki=0.10nM
BindingDB: IC50=0.300000nM,Ki=0.100000nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:6udi, PDBe:6udi, PDBj:6udi
PDBsum6udi
PubMed31736296
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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