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Structure of PDB 6pgr Chain A

Receptor sequence >6pgrA (length=347) Species: 9606 (Homo sapiens) [Search protein sequence] ALAAVLKHSSESTQVRGYDFNRGVNYRALLEAFGTTGFQATNFGRAVQQV NAMIEKKLEPLSQDEDQHADLTQSRRPLTSCTIFLGYTSNLISSGIRETI RYLVQHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRI GNLLVPNENYCKFEDWLMPILDQMVMEQNTEGVKWTPSKMIARLGKEINN PESVYYWAQKNHIPVFSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLI NTQAIFAKCTGMIILGGGVVKHHIANANLMRNGADYAVYINTAQEFDGSD SGARPDEAVSWGKIRVDAQPVKVYADASLVFPLLVAETFAQKMDAFM

3D structure PDB 6pgr Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase. Chain A Resolution 1.95 Å 3D structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Enzyme Commision number 2.5.1.46: deoxyhypusine synthase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 8XY A Y103 T104 V129 I266 N267 I280 V286 H288 K329 Y87 T88 V113 I250 N251 I264 V270 H272 K313 MOAD: ic50=0.062uM BindingDB: IC50=56000nM

Gene Ontology Molecular Function GO:0005515 protein binding GO:0016740 transferase activity GO:0034038 deoxyhypusine synthase activity GO:0042802 identical protein binding

	Biological Process
GO:0006412	translation
GO:0008216	spermidine metabolic process
GO:0008284	positive regulation of cell population proliferation
GO:0008612	peptidyl-lysine modification to peptidyl-hypusine
GO:0042102	positive regulation of T cell proliferation
GO:0042593	glucose homeostasis
GO:0046203	spermidine catabolic process

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

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