Structure of PDB 6m8b Chain A

Receptor sequence

>6m8bA (length=238) Species: 9606 (Homo sapiens) [Search protein sequence]

ILQHPDGTVLKQLQPPPRGPRELEFYNMVYAADCFDGVLLELRKYLPKYY
GIWSPPTAPNDLYLKLEDVTHKFNKPCIMDVKIGQKSYDPFASSEKIQQQ
VSKYPLMEEIGFLVLGMRVYHVHSDSYETENQHYGRSLTKETIKDGVSRF
FHNGYCLRKDAVAASIQKIEKILQWFENQKQLNFYASSLLFVYEGSSGGE
VEVRMIDFAHVFPSNTIDEGYVYGLKHLISVLRSILDN

3D structure

PDB

6m8b Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis.

Chain

Resolution

1.8 Å

3D
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Enzymatic activity

Enzyme Commision number

2.7.1.140: inositol-tetrakisphosphate 5-kinase.
2.7.1.151: inositol-polyphosphate multikinase.
2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	KMP	A	I65 Q67 P111 E131 D132 V133 I142 L254 I384	I1 Q3 P47 E67 D68 V69 I78 L190 I206	MOAD: ic50=4.4uM PDBbind-CN: -logKd/Ki=5.36,IC50=4.4uM BindingDB: IC50=4400nM

Gene Ontology

	Molecular Function
GO:0016301	kinase activity

	Biological Process
GO:0032958	inositol phosphate biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6m8b, PDBe:6m8b, PDBj:6m8b
PDBsum	6m8b
PubMed	30624931
UniProt	Q8NFU5\|IPMK_HUMAN Inositol polyphosphate multikinase (Gene Name=IPMK)

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