BioLiP

Structure of PDB 6e93 Chain A

Receptor sequence

>6e93A (length=112) Species: 9606 (Homo sapiens) [Search protein sequence]

PYACELCAKQFQSPSTLKMHMRCHTGEKPYQCKTCGRCFSVQGNLQKHER
IHLGLKEFVCQYCNKAFTLNETLKIHERIHTGEKRYHCQFCFQRFLYLST
KRNHEQRHIREH

3D structure

PDB

6e93 Structural insights into methylated DNA recognition by the C-terminal zinc fingers of the DNA reader protein ZBTB38.

Chain

Resolution

1.747 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	H1028 C1031 R1045 F1047 N1052 H1056 I1059 K1073 H1084 Y1105 T1108 N1111 R1115	H20 C23 R37 F39 N44 H48 I51 K65 H76 Y97 T100 N103 R107	PDBbind-CN: Kd=5nM
BS02	dna	A	Y1010 S1021 P1022 S1023 K1055 E1079 R1093	Y2 S13 P14 S15 K47 E71 R85	PDBbind-CN: Kd=5nM
BS03	ZN	A	C1068 C1071 H1084 H1088	C60 C63 H76 H80
BS04	ZN	A	C1040 C1043 H1056 H1060	C32 C35 H48 H52
BS05	ZN	A	C1096 C1099 H1112 H1116	C88 C91 H104 H108
BS06	ZN	A	C1012 C1015 H1028 H1032	C4 C7 H20 H24

External links

PDB	RCSB:6e93, PDBe:6e93, PDBj:6e93
PDBsum	6e93
PubMed	30355731
UniProt	Q8NAP3\|ZBT38_HUMAN Zinc finger and BTB domain-containing protein 38 (Gene Name=ZBTB38)

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