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Structure of PDB 5udk Chain A

Receptor sequence >5udkA (length=461) Species: 9606 (Homo sapiens) [Search protein sequence] HQVKDSLEQLRCHFTWELSIDDDEMPDLENRVLDQIEFLDTKYSVGIHNL LAYVKHLKGQNEEALKSLKEAENLMQEEHDNQANVRSLVTWGNFAWMYYH MGRLAEAQTYLDKVENICKKLSNPFRYRMECPEIDCEEGWALLKCGGKNY ERAKACFEKVLEVDPENPESSAGYAISAYRLDGFKLATKNHKPFSLLPLR QAVRLNPDNGYIKVLLALKLQDEGQEAEGEKYIEEALANMSSQTYVFRYA AKFYRRKGSVDKALELLKKALQETPTSVLLHHQIGLCYKAQMIQIKEATK GQPRGQNREKLDKMIRSAIFHFESAVEKKPTFEVAHLDLARMYIEAGNHR KAEENFQKLLCMKPVVEETMQDIHFHYGRFQEFQKKSDVNAIIHYLKAIK IEQASLTRDKSINSLKKLVLRKLRRKALDLESLSLLGFVYKLEGNMNEAE EYYERAERLAA

3D structure PDB 5udk Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations. Chain A Resolution 1.65 Å 3D structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Enzyme Commision number ?

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 rna A R38 K151 G154 Y157 R187 G190 F191 A194 Y218 R255 Y256 K259 R262 L286 H289 Q290 L293 K336 F339 V341 D345 V372 D379 R31 K144 G147 Y150 R180 G183 F184 A187 Y211 R248 Y249 K252 R255 L279 H282 Q283 L286 K329 F332 V334 D338 V365 D372

Gene Ontology Molecular Function GO:0003723 RNA binding GO:0005515 protein binding

	Biological Process
GO:0009615	response to virus
GO:0019060	intracellular transport of viral protein in host cell
GO:0032091	negative regulation of protein binding
GO:0045070	positive regulation of viral genome replication
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response
GO:0051097	negative regulation of helicase activity
GO:0051607	defense response to virus
GO:0051707	response to other organism
GO:0071357	cellular response to type I interferon
GO:0071360	cellular response to exogenous dsRNA
GO:0140374	antiviral innate immune response

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0043657	host cell

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