Structure of PDB 5twn Chain A

Receptor sequence

>5twnA (length=550) Species: 333284 (Hepatitis C virus (isolate Con1)) [Search protein sequence]

SMSYTWTGALITPCYATTSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKA
KASTVKAKLLSVEEACKLTPPHSARSKFGYGAKDVRNLSSKAVNHIRSVW
KDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKM
ALYDVVSTLPQAVMGSSYGFQYSPGQRVEFLVNAWKAKKCPMGFAYDTRC
FDSTVTENDIRVEESIYQCCDLAPEARQAIRSLTERLYIGGPLTNSKGQN
CGYRRCRASGVLTTSCGNTLTCYLKAAAACRAAKLQDCTMLVCGDDLVVI
CESAGTQEDEASLRAFTEAMTRYSAPPGDPPKPEYDLELITSCSSNVSVA
HDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLWARM
ILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIQRLHGLSAFS
LHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGK
YLFNWAVRTKLKLTPIPAASQLDLSSWFVAGYSGGDIYHSLSRARPRWFM

3D structure

PDB

5twn The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase.

Chain

Resolution

3.04 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	23E	A	A395 A396 I424 H428 L492 G493 V494 P495 P496 R498 V499 W500 R503	A372 A373 I401 H405 L469 G470 V471 P472 P473 R475 V476 W477 R480

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003968	RNA-dependent RNA polymerase activity

	Biological Process
GO:0039694	viral RNA genome replication

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Molecular Function

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Biological Process

External links

PDB	RCSB:5twn, PDBe:5twn, PDBj:5twn
PDBsum	5twn
PubMed	30108798
UniProt	Q9WMX2\|POLG_HCVCO Genome polyprotein

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