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BioLiP

Structure of PDB 5ntp Chain A

Receptor sequence
>5ntpA (length=230) Species: 9606 (Homo sapiens) [Search protein sequence]
PYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKS
MWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVL
VRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHF
SEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLSKTHRQSI
LAKLPPKGKLRSLCSQHVERLQIFQHLHPI
3D structure
PDB5ntp Structural States of ROR gamma t: X-ray Elucidation of Molecular Mechanisms and Binding Interactions for Natural and Synthetic Compounds.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 98E A L287 H323 M365 A368 V376 F377 F388 S404 H479 F486 L25 H61 M103 A106 V114 F115 F126 S142 H217 F224 MOAD: ic50=0.7nM
PDBbind-CN: -logKd/Ki=9.15,IC50=0.7nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:5ntp, PDBe:5ntp, PDBj:5ntp
PDBsum5ntp
PubMed28590087
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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