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Structure of PDB 5f1v Chain A

Receptor sequence >5f1vA (length=296) Species: 197 (Campylobacter jejuni) [Search protein sequence] KNIIIGAMTALITPFKNGKVDEQSYARLIKRQIENGIDAVVPVGTTGESA TLTHEEHRTCIEIAVETCKGTKVKVLAGAGSNATHEAVGLAKFAKEHGAD GILSVAPYYNKPTQQGLYEHYKAIAQSVDIPVLLYNVPGRTGCEISTDTI IKLFRDCENIYGVKEASGNIDKCVDLLAHEPRMMLISGEDAINYPILSNG GKGVISVTSNLLPDMISALTHFALDENYKEAKKINDELYNINKILFCESN PIPIKTAMYLAGLIESLEFRLPLCSPSKENFAKIEEVMKKYKIKGF

3D structure PDB 5f1v Biomimetic Design Results in a Potent Allosteric Inhibitor of Dihydrodipicolinate Synthase from Campylobacter jejuni. Chain A Resolution 2.2 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) T47 Y111 Y137 R142 K166 I207 Catalytic site (residue number reindexed from 1) T45 Y109 Y135 R140 K164 I205 Enzyme Commision number 4.3.3.7: 4-hydroxy-tetrahydrodipicolinate synthase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 3VN A K71 T73 K74 K76 G100 D102 K69 T71 K72 K74 G98 D100 MOAD: Ki~200nM PDBbind-CN: -logKd/Ki=6.85,Ki=140nM BS02 3VN A S51 A52 H56 H59 N84 E88 Y110 S49 A50 H54 H57 N82 E86 Y108 MOAD: Ki~200nM PDBbind-CN: -logKd/Ki=6.85,Ki=140nM

Gene Ontology Molecular Function GO:0008840 4-hydroxy-tetrahydrodipicolinate synthase activity GO:0016829 lyase activity

	Biological Process
GO:0009085	lysine biosynthetic process
GO:0009089	lysine biosynthetic process via diaminopimelate
GO:0019877	diaminopimelate biosynthetic process
GO:0044281	small molecule metabolic process

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

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