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BioLiP

Structure of PDB 5d25 Chain A

Receptor sequence
>5d25A (length=124) Species: 9606 (Homo sapiens) [Search protein sequence]
MNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKL
NLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKP
GDDIVLMAEALEKLFLQKINELPT
3D structure
PDB5d25 4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 56M A W81 P82 Q85 V87 K91 L92 N140 I146 W39 P40 Q43 V45 K49 L50 N98 I104 MOAD: Kd=0.46uM
PDBbind-CN: -logKd/Ki=6.30,Kd=0.50uM
BindingDB: Kd=460nM
BS02 BU3 A Q59 Q64 Q17 Q22
External links
PDB RCSB:5d25, PDBe:5d25, PDBj:5d25
PDBsum5d25
PubMed26731611
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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