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BioLiP

Structure of PDB 5cbz Chain A

Receptor sequence
>5cbzA (length=73) Species: 32644 (unidentified) [Search protein sequence]
SKVCLVCGDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDK
IRRKNCPACRLRKCLQAGMNLGA
3D structure
PDB5cbz Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A C431 H432 Y433 K442 K446 C14 H15 Y16 K25 K29 PDBbind-CN: Kd=0.106uM
BS02 dna A G439 S440 R447 Y455 R470 K471 R477 G22 S23 R30 Y38 R53 K54 R60 PDBbind-CN: Kd=0.106uM
BS03 ZN A C421 C424 C438 C441 C4 C7 C21 C24
BS04 ZN A C457 C463 C473 C476 C40 C46 C56 C59
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5cbz, PDBe:5cbz, PDBj:5cbz
PDBsum5cbz
PubMed26715749
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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