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Structure of PDB 4ufb Chain A

Receptor sequence >4ufbA (length=603) Species: 9606 (Homo sapiens) [Search protein sequence] LDPGLQPGQFSADEAGAQLFAQSYQSSAEQVLFQSVAASWAHDTNITAEN ARRQEEAALLSQEFAEAWGQKAKELYEPIWQQFTDPQLRRIIGAVRTLGS ANLPLAKRQQYNALLSQMSRIYSTAKVCLTCWSLDPDLTNILASSRSYAM LLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNSP TFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGD MWAQSWENIYDMVVPFPDKPNLDVTSTMLQQGWQATHMFRVAEEFFTSLE LSPMPPEFWEGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQ LSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVSTPEHL HKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTP PSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSF VLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLRAGSSRPWQEV LKDMVGLDALDAQPLLKYFQLVTQWLQEQNQQNGEVLGWPEYQWHPPLPD NYP

3D structure PDB 4ufb Structural Basis of Ac-Sdkp Hydrolysis by Angiotensin-I Converting Enzyme Chain A Resolution 1.8 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) H331 A332 H361 E362 H365 E389 H491 Y501 Catalytic site (residue number reindexed from 1) H326 A327 H356 E357 H360 E384 H486 Y496 Enzyme Commision number 3.4.15.1: peptidyl-dipeptidase A.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 LYS A H331 A332 T358 H361 E362 H491 H326 A327 T353 H356 E357 H486 BS02 PRO A Q259 F435 K489 H491 Y498 Y501 Q254 F430 K484 H486 Y493 Y496 BindingDB: Ki=86000nM BS03 ZN A H361 H365 E389 H356 H360 E384

Gene Ontology Molecular Function GO:0008237 metallopeptidase activity GO:0008241 peptidyl-dipeptidase activity

	Biological Process
GO:0006508	proteolysis

	Cellular Component
GO:0016020	membrane

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