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Structure of PDB 4g8y Chain A

Receptor sequence >4g8yA (length=124) Species: 9913 (Bos taurus) [Search protein sequence] KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHES LADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTT QANKHIIVACEGNPYVPVHFDASV

3D structure PDB 4g8y Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation. Chain A Resolution 1.8 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) H12 K41 H119 F120 D121 Catalytic site (residue number reindexed from 1) H12 K41 H119 F120 D121 Enzyme Commision number 4.6.1.18: pancreatic ribonuclease.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 0FT A Q11 H12 K41 N44 T45 H119 F120 Q11 H12 K41 N44 T45 H119 F120 MOAD: Ki=25.8uM PDBbind-CN: -logKd/Ki=4.59,Ki=25.8uM

Gene Ontology Molecular Function GO:0003676 nucleic acid binding GO:0004519 endonuclease activity GO:0004522 ribonuclease A activity GO:0004540 RNA nuclease activity GO:0005515 protein binding GO:0016829 lyase activity

	Biological Process
GO:0050830	defense response to Gram-positive bacterium

	Cellular Component
GO:0005576	extracellular region

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