Structure of PDB 2qs3 Chain A

Receptor sequence

>2qs3A (length=251) Species: 10116 (Rattus norvegicus) [Search protein sequence]

RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDV
KLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSK
PFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKIST
YEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCN
LTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRG
N

3D structure

PDB

2qs3 ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function.

Chain

Resolution

1.76 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	UBE	A	Y61 P88 L89 T90 R95 V137 G140 S141 T142 N172	Y58 P85 L86 T87 R92 V134 G137 S138 T139 N169	MOAD: Kd=1.4nM BindingDB: Kd=12nM

Gene Ontology

	Molecular Function
GO:0015276	ligand-gated monoatomic ion channel activity

	Cellular Component
GO:0016020	membrane

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Molecular Function

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Cellular Component

External links

PDB	RCSB:2qs3, PDBe:2qs3, PDBj:2qs3
PDBsum	2qs3
PubMed	18789344
UniProt	P22756\|GRIK1_RAT Glutamate receptor ionotropic, kainate 1 (Gene Name=Grik1)

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