Structure of PDB 2ovy Chain A

Receptor sequence

>2ovyA (length=305) Species: 10116 (Rattus norvegicus) [Search protein sequence]

NLPARICRDIELFHFDIGPFENMWPGIFVYMIHRSCGTSCFELEKLCRFI
MSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNNGLFTDLERKGLLIACLC
HDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFS
TLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHNQSHR
DRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIP
MMDRDKRDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQW
EKVIR

3D structure

PDB

2ovy Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors

Chain

Resolution

1.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	H519 H553 D554 D664	H67 H101 D102 D212
BS02	PFJ	A	F629 L665 F686 M703 Q716 G718 F719 A722 V723	F177 L213 F234 M251 Q264 G266 F267 A270 V271	MOAD: Ki=4nM PDBbind-CN: -logKd/Ki=8.40,Ki=4nM BindingDB: Ki=4nM

Gene Ontology

	Molecular Function
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081	phosphoric diester hydrolase activity

	Biological Process
GO:0007165	signal transduction

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:2ovy, PDBe:2ovy, PDBj:2ovy
PDBsum	2ovy
PubMed	17228859
UniProt	Q9QYJ6\|PDE10_RAT cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Gene Name=Pde10a)

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