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Structure of PDB 2gsm Chain A

Receptor sequence >2gsmA (length=535) Species: 1063 (Cereibacter sphaeroides) [Search protein sequence] FTRWFMSTNHKDIGVLYLFTGGLVGLISVAFTVYMRMELMAPGVQFMCAE HLESGLVKGFFQSLWPSAVENCTPNGHLWNVMITGHGILMMFFVVIPALF GGFGNYFMPLHIGAPDMAFPRMNNLSYWLYVAGTSLAVASLFAPGGNGQL GSGIGWVLYPPLSTSESGYSTDLAIFAVHLSGASSILGAINMITTFLNMR APGMTMHKVPLFAWSIFVTAWLILLALPVLAGAITMLLTDRNFGTTFFQP SGGGDPVLYQHILWFFGHPEVYIIVLPAFGIVSHVIATFAKKPIFGYLPM VYAMVAIGVLGFVVWAHHMYTAGLSLTQQSYFMMATMVIAVPTGIKIFSW IATMWGGSIELKTPMLWALGFLFLFTVGGVTGIVLSQASVDRYYHDTYYV VAHFHYVMSLGAVFGIFAGIYFWIGKMSGRQYPEWAGKLHFWMMFVGANL TFFPQHFLGRQGMPRRYIDYPEAFATWNFVSSLGAFLSFASFLFFLGVIF YTLTRGARVTANNYWNEHADTLEWTLTSPPPEHTF

3D structure PDB 2gsm Identification of conserved lipid/detergent-binding sites in a high-resolution structure of the membrane protein cytochrome c oxidase. Chain A Resolution 2.0 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) Y33 I43 F47 M51 I99 H102 N121 D132 N139 S142 Y146 W172 S200 S201 G204 T211 H284 E286 Y288 S299 P315 H333 H334 T359 K362 H419 F420 H421 R481 Catalytic site (residue number reindexed from 1) Y17 I27 F31 M35 I83 H86 N105 D116 N123 S126 Y130 W156 S184 S185 G188 T195 H268 E270 Y272 S283 P299 H317 H318 T343 K346 H403 F404 H405 R465 Enzyme Commision number 7.1.1.9: cytochrome-c oxidase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 DMU A W451 F510 Y517 W435 F494 Y501 BS02 DMU A W451 F510 W435 F494 BS03 DMU A M443 S444 M427 S428 BS04 CU A H284 H333 H334 H268 H317 H318 BS05 MG A H411 D412 H395 D396 BS06 CA A E54 A57 G59 Q61 E38 A41 G43 Q45 BS07 HEA A G38 T48 M51 R52 W95 I99 H102 M106 M107 G171 W172 Y414 F420 H421 M424 S425 V429 M460 F468 R481 R482 S504 G22 T32 M35 R36 W79 I83 H86 M90 M91 G155 W156 Y398 F404 H405 M408 S409 V413 M444 F452 R465 R466 S488 BS08 HEA A W172 W280 V287 Y288 V291 H333 H334 I355 G360 G395 G398 I399 L401 S402 D407 H411 V416 H419 F420 V423 M424 R481 W156 W264 V271 Y272 V275 H317 H318 I339 G344 G379 G382 I383 L385 S386 D391 H395 V400 H403 F404 V407 M408 R465 BS09 DMU A F364 W371 F348 W355

Gene Ontology Molecular Function GO:0004129 cytochrome-c oxidase activity GO:0005515 protein binding GO:0020037 heme binding GO:0046872 metal ion binding

	Biological Process
GO:0006119	oxidative phosphorylation
GO:0009060	aerobic respiration
GO:0015990	electron transport coupled proton transport
GO:0022904	respiratory electron transport chain
GO:1902600	proton transmembrane transport

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0045277	respiratory chain complex IV

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