BioLiP

Structure of PDB 2as4 Chain A

Receptor sequence

>2as4A (length=291) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]

LVHVASVEKGRSYEDFQKVYNAIALKLREDDEYDNYIGYGPVLVRLAWHI
SGTWDKHDNTGGSYGGTYRFKKEFNDPSNAGLQNGFKFLEPIHKEFPWIS
SGDLFSLGGVTAVQEMQGPKIPWRCGRVDTPEDTTPDNGRLPDADKDAGY
VRTFFQRLNMNDREVVALMGAHALGKTHLKNSGYEGPGGAANNVFTNEFY
LNLLNEDWKLEKNDANNEQWDSKSGYMMLPTDYSLIQDPKYLSIVKEYAN
DQDKFFKDFSKAFEKLLENGITFPKDAPSPFIFKTLEEQGL

3D structure

PDB

2as4 Probing molecular docking in a charged model binding site.

Chain

Resolution

1.3 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	R48 H52 H175 G191 D235
Catalytic site (residue number reindexed from 1)	R45 H49 H172 G188 D232
Enzyme Commision number	1.11.1.5: cytochrome-c peroxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	HEM	A	P44 R48 W51 P145 D146 A147 L171 M172 A174 H175 G178 K179 T180 H181 N184 S185 L232	P41 R45 W48 P142 D143 A144 L168 M169 A171 H172 G175 K176 T177 H178 N181 S182 L229
BS02	3FA	A	H175 G178 K179 T180 P190 G191 M230 L232 D235	H172 G175 K176 T177 P187 G188 M227 L229 D232	MOAD: Kd=7.7mM
BS03	3FA	A	F89 E93 H96 S104 L107 F108	F86 E90 H93 S101 L104 F105	MOAD: Kd=7.7mM

Gene Ontology

	Molecular Function
GO:0004601	peroxidase activity
GO:0020037	heme binding

	Biological Process
GO:0006979	response to oxidative stress
GO:0034599	cellular response to oxidative stress

View graph for
Molecular Function

View graph for
Biological Process

PDB	RCSB:2as4, PDBe:2as4, PDBj:2as4
PDBsum	2as4
PubMed	16490206
UniProt	P00431\|CCPR_YEAST Cytochrome c peroxidase, mitochondrial (Gene Name=CCP1)