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Structure of PDB 1yjs Chain A

Receptor sequence >1yjsA (length=405) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence] MKYLPQQDPQVFAAIEQERKRQHAKIELIASENFVSRAVMEAQGSVLTNK YAEGYPGRRYYGGCEYVDIVEELARERAKQLFGAEHANVQPHSGAQANMA VYFTVLEHGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVAYGVDPETHVI DYDDVREKARLHRPKLIVAAASAYPRIIDFAKFREIADEVGAYLMVDMAH IAGLVAAGLHPNPVPYAHFVTTTTHQTLRGPRGGMILCQEQFAKQIDKAI FPGIQGGPLMHVIAAKAVAFGEALQDDFKAYAKRVVDNAKRLASALQNEG FTLVSGGTDNHLLLVDLRPQQLTGKTAEKVLDEVGITVNKNTIPYDPESP FVTSGIRIGTAAVTTRGFGLEEMDEIAAIIGLVLKNVGSEQALEEARQRV AALTD

3D structure PDB 1yjs Role of Lys-226 in the Catalytic Mechanism of Bacillus Stearothermophilus Serine Hydroxymethyltransferase-Crystal Structure and Kinetic Studies Chain A Resolution 2.0 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) Y51 E53 D197 T223 Q226 R232 Catalytic site (residue number reindexed from 1) Y51 E53 D197 T223 Q226 R232 Enzyme Commision number 2.1.2.1: glycine hydroxymethyltransferase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 PLP A G94 A95 H122 S172 D197 A199 H200 T223 H225 G94 A95 H122 S172 D197 A199 H200 T223 H225 BS02 GLY A S31 H200 R357 S31 H200 R357

Gene Ontology Molecular Function GO:0003824 catalytic activity GO:0004372 glycine hydroxymethyltransferase activity GO:0008270 zinc ion binding GO:0016740 transferase activity GO:0030170 pyridoxal phosphate binding GO:0050897 cobalt ion binding GO:0070905 serine binding

	Biological Process
GO:0006545	glycine biosynthetic process
GO:0006565	L-serine catabolic process
GO:0006730	one-carbon metabolic process
GO:0008652	amino acid biosynthetic process
GO:0019264	glycine biosynthetic process from serine
GO:0035999	tetrahydrofolate interconversion
GO:0046653	tetrahydrofolate metabolic process
GO:0046655	folic acid metabolic process

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

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