Structure of PDB 1fpu Chain A

Receptor sequence

>1fpuA (length=275) Species: 10090 (Mus musculus) [Search protein sequence]

MDPSSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK
EDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLL
DYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN
HLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWA
FGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRA
CWQWNPSDRPSFAEIHQAFETMFQE

3D structure

PDB

1fpu Structural mechanism for STI-571 inhibition of abelson tyrosine kinase.

Chain

Resolution

2.4 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	D363 A365 R367 N368 D381 P402
Catalytic site (residue number reindexed from 1)	D139 A141 R143 N144 D157 P178
Enzyme Commision number	2.7.10.2: non-specific protein-tyrosine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PRC	A	L248 Y253 A269 K271 E286 M290 I313 T315 F317 M318 D381 F382	L24 Y29 A45 K47 E62 M66 I89 T91 F93 M94 D157 F158	MOAD: Ki=37nM

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1fpu, PDBe:1fpu, PDBj:1fpu
PDBsum	1fpu
PubMed	10988075
UniProt	P00520\|ABL1_MOUSE Tyrosine-protein kinase ABL1 (Gene Name=Abl1)

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