Structure of PDB 1cwr Chain A

Receptor sequence

>1cwrA (length=177) Species: 9606 (Homo sapiens) [Search protein sequence]

DHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVI
VDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHC
EFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFC
EPQDYRPMNHEAFKDELKTFRLKTRSW

3D structure

PDB

1cwr Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle.

Chain

Resolution

2.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.3.48: protein-tyrosine-phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SO4	A	R488 R492 W550	R115 R119 W177

Gene Ontology

	Molecular Function
GO:0004725	protein tyrosine phosphatase activity

	Biological Process
GO:0006470	protein dephosphorylation
GO:1902751	positive regulation of cell cycle G2/M phase transition

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1cwr, PDBe:1cwr, PDBj:1cwr
PDBsum	1cwr
PubMed	10543950
UniProt	P30305\|MPIP2_HUMAN M-phase inducer phosphatase 2 (Gene Name=CDC25B)

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