Structure of PDB 1c4u Chain 2

Receptor sequence

>1c4u2 (length=252) Species: 9606 (Homo sapiens) [Search protein sequence]

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
GE

3D structure

PDB

1c4u Structure of thrombin complexed with selective non-electrophilic inhibitors having cyclohexyl moieties at P1.

Chain

Resolution

2.1 Å

3D
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Enzymatic activity

Enzyme Commision number

3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	2	F34 Q38 L40 R67 R73 T74 R75 Y76 K81 I82	F19 Q24 L26 R62 R68 T69 R70 Y71 K77 I78
BS02	IH1	2	H57 Y60A W60D E97A N98 L99 D189 A190 S214 W215 G216 G219	H43 Y47 W50 E94 N95 L96 D192 A193 S219 W220 G221 G223	MOAD: Ki=0.043nM PDBbind-CN: -logKd/Ki=10.37,Ki=0.043nM

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding

	Biological Process
GO:0006508	proteolysis
GO:0007596	blood coagulation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1c4u, PDBe:1c4u, PDBj:1c4u
PDBsum	1c4u
PubMed	10713516
UniProt	P00734\|THRB_HUMAN Prothrombin (Gene Name=F2)

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