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BioLiP

Structure of PDB 6veq Chain K Binding Site BS03

Receptor Information
>6veq Chain K (length=287) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKL
IMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKEL
GLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKDDNEE
CGDICNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSEC
LGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDL
HHKQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCP
Ligand information
>6veq Chain H (length=17) Species: 6491 (Conus geographus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PKHRCGSEITNSYMDLC
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6veq A structurally minimized yet fully active insulin based on cone-snail venom insulin principles.
Resolution3.25 Å
Binding residue
(original residue number in PDB)		L37 F39 R65
Binding residue
(residue number reindexed from 1)		L33 F35 R61
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
External links
PDB RCSB:6veq, PDBe:6veq, PDBj:6veq
PDBsum6veq
PubMed32483339
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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