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Structure of PDB 2c2b Chain F Binding Site BS03

Receptor Information >2c2b Chain F (length=444) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] VNPFSAKYVPFNAAPGSTESYSLDEIVYRSRSGGLLDVEHDMEALKRFDG AYWRDLFDSRVGKSTWPYGSGVWSKKEWVLPEIDDDDIVSAFEGNSNLFW AERFGKQFLGMNDLWVKHCGISHTGSFKDLGMTVLVSQVNRLRKMKRPVV GVGCASTGDTSAALSAYCASAGIPSIVFLPANKISMAQLVQPIANGAFVL SIDTDFDGCMKLIREITAELPIYLANSLNSLRLEGQKTAAIEILQQFDWQ VPDWVIVPGGNLGNIYAFYKGFKMCQELGLVDRIPRMVCAQAANANPLYL HYKSGWKDFKPMTASTTFASAIQIGDPVSIDRAVYALKKCNGIVEEATEE ELMDAMAQADSTGMFICPHTGVALTALFKLRNQGVIAPTDRTVVVSTAHG LKFTQSKIDYHSNAIPDMACRFSNPPVDVKADFGAVMDVLKSYL

Ligand information Ligand ID PLP InChI InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14) InChIKey NGVDGCNFYWLIFO-UHFFFAOYSA-N SMILES Software SMILES CACTVS 3.341 Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O OpenEye OEToolkits 1.5.0 Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O ACDLabs 10.04 O=P(O)(O)OCc1cnc(c(O)c1C=O)C Formula C8 H10 N O6 P Name PYRIDOXAL-5'-PHOSPHATE; VITAMIN B6 Phosphate ChEMBL CHEMBL82202 DrugBank DB00114 ZINC ZINC000001532514 PDB chain 2c2b Chain F Residue 1163 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 2c2b Allosteric Threonine Synthase: Reorganization of the Pyridoxal Phosphate Site Upon Asymmetric Activation Through S-Adenosylmethionine Binding to a Novel Site. Resolution 2.6 Å Binding residue (original residue number in PDB) F162 K163 D194 G294 G295 N296 L297 G298 N299 A356 H404 T432 Binding residue (residue number reindexed from 1) F127 K128 D159 G259 G260 N261 L262 G263 N264 A321 H369 T397 Annotation score 1

Enzymatic activity Enzyme Commision number 4.2.3.1: threonine synthase.

Gene Ontology Molecular Function GO:0004795 threonine synthase activity GO:0016829 lyase activity GO:0030170 pyridoxal phosphate binding

	Biological Process
GO:0006520	amino acid metabolic process
GO:0009088	threonine biosynthetic process

	Cellular Component
GO:0005886	plasma membrane
GO:0009507	chloroplast
GO:0009570	chloroplast stroma

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