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Structure of PDB 2yne Chain C Binding Site BS03

Receptor Information >2yne Chain C (length=367) Species: 5855 (Plasmodium vivax) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] DYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVC DVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWH IGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAP VLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGF VEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPI ENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTA TFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLY NWKCASFAPAHVGIVLL

Ligand information Ligand ID MG InChI InChI=1S/Mg/q+2 InChIKey JLVVSXFLKOJNIY-UHFFFAOYSA-N SMILES Software SMILES ACDLabs 10.04 OpenEye OEToolkits 1.5.0 [Mg+2] CACTVS 3.341 [Mg++] Formula Mg Name MAGNESIUM ION ChEMBL DrugBank DB01378 ZINC PDB chain 2yne Chain C Residue 1411 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 2yne Validation of N-Myristoyltransferase as an Antimalarial Drug Target Using an Integrated Chemical Biology Approach. Resolution 1.72 Å Binding residue (original residue number in PDB) L169 R170 K172 L174 Binding residue (residue number reindexed from 1) L143 R144 K146 L148 Annotation score 1

Enzymatic activity Catalytic site (original residue number in PDB) N161 F162 L163 T197 L410 Catalytic site (residue number reindexed from 1) N135 F136 L137 T171 L367 Enzyme Commision number 2.3.1.97: glycylpeptide N-tetradecanoyltransferase.

Gene Ontology Molecular Function GO:0004379 glycylpeptide N-tetradecanoyltransferase activity GO:0016746 acyltransferase activity GO:0046872 metal ion binding

	Biological Process
GO:0006499	N-terminal protein myristoylation
GO:0018008	N-terminal peptidyl-glycine N-myristoylation

	Cellular Component
GO:0005737	cytoplasm

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