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●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

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Structure of PDB 7pg0 Chain B Binding Site BS03

Receptor Information >7pg0 Chain B (length=822) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKD DNEECGDICPGTNCPATQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCH SECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFC QDLHHKCKCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLL EGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEIS GYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWS KHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQ ASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNV TEFDGQDACGSNSWTVVDIDPPLRQNHPGWLMRGLKPWTQYAIFVKTLVT FSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDP NGNITHYLVFWERQAEDSELFELDYCYEDSAGECCSCPKTDSQILKELEE SSFRKTFEDYLHNVVFVPRPHRPFEKVVNKESLVISGLRHFTGYRIELQA CNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEP KEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVR IRATSLAGNGSWTEPTYFYVTD

Ligand information >7pg0 Chain E (length=21) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] GIVEQCCTSICSLYQLENYCN

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 7pg0 Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling. Resolution 7.6 Å Binding residue (original residue number in PDB) Q34 L36 L37 F39 L62 F64 F88 F89 R118 Binding residue (residue number reindexed from 1) Q34 L36 L37 F39 L62 F64 F88 F89 R118

Enzymatic activity Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.

Gene Ontology Molecular Function GO:0004672 protein kinase activity GO:0004713 protein tyrosine kinase activity GO:0004714 transmembrane receptor protein tyrosine kinase activity GO:0005524 ATP binding GO:0043548 phosphatidylinositol 3-kinase binding GO:0043560 insulin receptor substrate binding

	Biological Process
GO:0006468	protein phosphorylation
GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway
GO:0046777	protein autophosphorylation

	Cellular Component
GO:0016020	membrane

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