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BioLiP

Structure of PDB 1ad5 Chain A Binding Site BS03

Receptor Information
>1ad5 Chain A (length=438) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYI
PSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKG
SYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKK
GNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWM
ATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEP
IYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYI
HRDLRAANILVSASLVCKIADFGLARVGAKFPIKWTAPEAINFGSFTIKS
DVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYN
IMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1ad5 Chain B Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1ad5 Crystal structure of the Src family tyrosine kinase Hck.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		E524 Y527 Q529
Binding residue
(residue number reindexed from 1)		E431 Y434 Q436
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404 G406 P425
Catalytic site (residue number reindexed from 1) D303 R305 A307 N308 D321 G323 P332
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:1ad5, PDBe:1ad5, PDBj:1ad5
PDBsum1ad5
PubMed9024658
UniProtP08631|HCK_HUMAN Tyrosine-protein kinase HCK (Gene Name=HCK)

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