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Structure of PDB 2h7f Chain X Binding Site BS02

Receptor Information >2h7f Chain X (length=314) Species: 10255 (Variola virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] MRALFYKDGKLFTDNNFLNPVSDNNPAYEVLQHVKIPTHLTDVVVYGQTW EEALTRLIFVGSDSKGRRQYFYGKMHVQNRNAKRDRIFVRVYNVMKRINS FINKNIKKSSTDSNYQLAVFMLMETMFFIRFGKMKYLKENETVGLLTLKN KHIEISPDKIVIKFVGKDKVSHEFVVHKSNRLYKPLLKLTDDSSPEEFLF NKLSERKVYESIKQFGIRIKDLRTYGVNYTFLYNFWTNVKSISPLPSPKK LIALTIKQTAEVVGHTPSISKRAYMATTILEMVKDKNFLDVVSKTTFDEF LSIVVDHVKSSTDG

Ligand information >2h7f Chain Z (length=14) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] taataagggcgaca

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 2h7f Structural basis for specificity in the poxvirus topoisomerase. Resolution 2.7 Å Binding residue (original residue number in PDB) H39 R67 Q69 R130 F131 G132 K133 Y136 N140 T142 K167 D168 K220 Binding residue (residue number reindexed from 1) H39 R67 Q69 R130 F131 G132 K133 Y136 N140 T142 K167 D168 K220

Enzymatic activity Catalytic site (original residue number in PDB) R130 Catalytic site (residue number reindexed from 1) R130 Enzyme Commision number 5.6.2.1: DNA topoisomerase.

Gene Ontology Molecular Function GO:0003677 DNA binding GO:0003916 DNA topoisomerase activity GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity

	Biological Process
GO:0006265	DNA topological change

	Cellular Component
GO:0044423	virion component

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