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●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

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Structure of PDB 8jd6 Chain R Binding Site BS02

Receptor Information >8jd6 Chain R (length=774) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] NSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRIN NDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIERVVGVIGASGSS VSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMV DIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREP KAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMG SDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNI WFAEFWEDNFHCKLVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHAL HAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGD APGRYDIYQYQLRAEYKVIGSWTDHLHLRIERMHWLPRSICSLPCQPGER KKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPII KLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVL LAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYR IFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDF QDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPE TFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLS ASVSLGMLYMPKVYIILFHPEQNV

Ligand information Ligand ID SEP InChI InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 InChIKey BZQFBWGGLXLEPQ-REOHCLBHSA-N SMILES Software SMILES ACDLabs 10.04 O=P(O)(O)OCC(C(=O)O)N OpenEye OEToolkits 1.5.0 C(C(C(=O)O)N)OP(=O)(O)O CACTVS 3.341 N[CH](CO[P](O)(O)=O)C(O)=O CACTVS 3.341 N[C@@H](CO[P](O)(O)=O)C(O)=O OpenEye OEToolkits 1.5.0 C([C@@H](C(=O)O)N)OP(=O)(O)O Formula C3 H8 N O6 P Name PHOSPHOSERINE; PHOSPHONOSERINE ChEMBL CHEMBL284377 DrugBank DB04522 ZINC ZINC000003869280 PDB chain 8jd6 Chain R Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 8jd6 Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers. Resolution 3.4 Å Binding residue (original residue number in PDB) S157 S159 A180 Y230 S313 K405 Binding residue (residue number reindexed from 1) S97 S99 A120 Y170 S253 K335 Annotation score 4

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity GO:0004930 G protein-coupled receptor activity GO:0008066 glutamate receptor activity

	Biological Process
GO:0007186	G protein-coupled receptor signaling pathway
GO:0007196	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
GO:0007216	G protein-coupled glutamate receptor signaling pathway
GO:0007268	chemical synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0043410	positive regulation of MAPK cascade
GO:0043523	regulation of neuron apoptotic process
GO:0051966	regulation of synaptic transmission, glutamatergic

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0031410	cytoplasmic vesicle
GO:0045202	synapse
GO:0098793	presynapse

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