BioLiP

Structure of PDB 2gws Chain M Binding Site BS02

Receptor Information

>2gws Chain M (length=326) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEA
CSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTA
QMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTV
QKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLD
SLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVPYSEF
ACALLYFTGSAHFNRSMRALAKTKGMSLSEHALSTAVVRNTHGCKVGPGR
VLPTPTEKDVFRLLGLPYREPAERDW

Ligand information

>2gws Chain R (length=6) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gtgcgg

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2gws Promiscuous mismatch extension by human DNA polymerase lambda.
Resolution	2.4 Å
Binding residue (original residue number in PDB)	W342 G343 A344 G345 K347 T348 R488
Binding residue (residue number reindexed from 1)	W93 G94 A95 G96 K98 T99 R239

Enzymatic activity

Catalytic site (original residue number in PDB)	D427 D429 D490
Catalytic site (residue number reindexed from 1)	D178 D180 D241
Enzyme Commision number	2.7.7.7: DNA-directed DNA polymerase. 4.2.99.-

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0016779	nucleotidyltransferase activity
GO:0034061	DNA polymerase activity

	Biological Process
GO:0006281	DNA repair

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Molecular Function

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Biological Process

PDB	RCSB:2gws, PDBe:2gws, PDBj:2gws
PDBsum	2gws
PubMed	16807316
UniProt	Q9UGP5\|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)