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●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

Structure of PDB 8sr7 Chain C Binding Site BS02

Receptor Information >8sr7 Chain C (length=1375) Species: 946362 (Salpingoeca rosetta) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] SVAAKTLLIENEDGKGSTRMEVQDFMKRFHMHASEDDKTGSPSTAWGTLR FPTKEATAPYLRLSVNDDPEDALLFVKAMLAQKYGETYDRPSLILSVTGG ARNFTLPPRLETAIAKGLRLAAQRTNAWVVTGGTNTGVMKLTGQIMEALS KTQSHFIPPTIGIATYGVIIGGDDMTRGEPPKIGLEYEMHKKDPPKTTPL DDNHNLFLLVDDGSTNKFGKEIKFRAAFENAAGQAFAAPVVTIVVQGGPG TLGTALQAVRQGTPIVVVDGSGLAADVLAYAYNFMHNPLTRFKSYTIDDL RQKVAQTFNPKSSQQLTNLLDSALECVQDPNLVVVYSLQESGIDEFDDCI LKAIFSSQGKLGNKLKQAMYFDQLDVAKRALSEASKNGQHNEIAACINDN LMAAMMHNKPHFVELYLGFDAKIYELKPSEEVAKTNITALDELPSFALAI EELYKREAKKPHSHVQRLVSLSNTDVLGRHYRGRDLANTRAYNVLRMDQI FARLVSKDFSVNRDFTIYDSKYDKVPGIQFRRTAQASHMLFLWAICLDRF RMARHFWLIGDQSIINALVASRILERLSTHRALQGPHLAEERAKMQHNAK KFEELAVGVLGECHGSDSHMASEMLHSKNDMFNKKNAINIAYDAKSLAFL SHPATQSVINADWYGHLKSVTSFWAVLFAFFFPFFVLPFINFSGAHRLRR KFAKFYSAPYTRFISDLLSHFVLCVVTSYFVLDKLEDTISAIEWILLVWF VALLLEELRQMIFCDGIAEYISDTWNRLDLIMITLFFVGFFTHASDPSNQ DSKVVSKGIHAFLVVVLWLRFMRYYALSKNLGPKLIMMMEMMKDVSTFVF LLLIFLIGYGVAAQSLLSPDEDFSSRTFIGVLFRPYFQIYGELFLDDLNS EANCLGDTPFTECSRETVRMVPFFLAVYILGSNVLLVNLLIAMFNDTYMK VQEAAEDLWRKQNYELCAEYKDRPFLPAPFILLAHVHMLFMRLLRLCGVH TQEHEKIQDDETKRKITTFEELNTDKFLRRWERERQEMLEARVKMTNDNV VQAMGMMDQLLEHMISFRFSLDQQATKINRLNSAVAVHGHTAEAAEWYVP PEEYPKSGGVKRYLIDASMVPLSIMCPSYDPVEYTHPSVAAQPVWADPAD PRKIKFNVKDEVNGKVVDRTSCHPSGISIDSNTGRPINPWGRTGMTGRGL LGKWGVNQAADTVVTRWKRSPDGSILERDGKKVLEFVAIQRQDNKMWAIP GGFVDNGEDVALTSGREFMEEALGMGTSADLMSAESKDSLAALFSSGTIV ARIYCEDPRNTDNAWVETTCVNFHDESGRHAARLKLQGGDDAEHARWMMV HGGLNLFASHRTLLQHVTSALNAYF

Ligand information Ligand ID RP5 InChI InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5-/m1/s1 InChIKey KTVPXOYAKDPRHY-TXICZTDVSA-N SMILES Software SMILES CACTVS 3.370 O[CH]1O[CH](CO[P](O)(O)=O)[CH](O)[CH]1O OpenEye OEToolkits 1.7.0 C([C@@H]1[C@H]([C@H]([C@@H](O1)O)O)O)OP(=O)(O)O OpenEye OEToolkits 1.7.0 C(C1C(C(C(O1)O)O)O)OP(=O)(O)O CACTVS 3.370 O[C@@H]1O[C@H](CO[P](O)(O)=O)[C@@H](O)[C@H]1O ACDLabs 12.01 O=P(O)(O)OCC1OC(O)C(O)C1O Formula C5 H11 O8 P Name 5-O-phosphono-beta-D-ribofuranose; [(2R,3S,4S,5R)-3,4,5-TRIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN PHOSPHATE; 5-O-phosphono-beta-D-ribose; 5-O-phosphono-D-ribose; 5-O-phosphono-ribose ChEMBL CHEMBL1235722 DrugBank DB04352 ZINC ZINC000004228241 PDB chain 8sr7 Chain C Residue 1501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 8sr7 Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution Resolution 1.97 Å Binding residue (original residue number in PDB) D1330 R1360 F1372 C1424 R1428 F1476 H1479 Binding residue (residue number reindexed from 1) D1211 R1241 F1253 C1305 R1309 F1357 H1360 Annotation score 1

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0005216 monoatomic ion channel activity GO:0005261 monoatomic cation channel activity GO:0005262 calcium channel activity

	Biological Process
GO:0006811	monoatomic ion transport
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0098655	monoatomic cation transmembrane transport

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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