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Structure of PDB 1a49 Chain C Binding Site BS02

Receptor Information >1a49 Chain C (length=519) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] IQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVETLK EMIKSGMNVARMNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVAL DTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYK NICKVVDVGSKVYVDDGLISLQVKQKGPDFLVTEVENGGFLGSKKGVNLP GAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKILGEKG KNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKM IIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLS GETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELARSSSHSTDLMEAM AMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNHQTARQ AHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVL TGWRPGSGFTNTMRVVPVP

Ligand information Ligand ID MG InChI InChI=1S/Mg/q+2 InChIKey JLVVSXFLKOJNIY-UHFFFAOYSA-N SMILES Software SMILES ACDLabs 10.04 OpenEye OEToolkits 1.5.0 [Mg+2] CACTVS 3.341 [Mg++] Formula Mg Name MAGNESIUM ION ChEMBL DrugBank DB01378 ZINC PDB chain 1a49 Chain C Residue 1734 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1a49 Structure of the bis(Mg2+)-ATP-oxalate complex of the rabbit muscle pyruvate kinase at 2.1 A resolution: ATP binding over a barrel. Resolution 2.1 Å Binding residue (original residue number in PDB) E1471 D1495 Binding residue (residue number reindexed from 1) E260 D284 Annotation score 1

Enzymatic activity Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase. 2.7.11.1: non-specific serine/threonine protein kinase. 2.7.1.40: pyruvate kinase.

Gene Ontology Molecular Function GO:0000287 magnesium ion binding GO:0003729 mRNA binding GO:0003824 catalytic activity GO:0004713 protein tyrosine kinase activity GO:0004743 pyruvate kinase activity GO:0005515 protein binding GO:0005524 ATP binding GO:0016301 kinase activity GO:0030955 potassium ion binding GO:0046872 metal ion binding

	Biological Process
GO:0006096	glycolytic process
GO:0006417	regulation of translation
GO:0016310	phosphorylation
GO:0032869	cellular response to insulin stimulus
GO:1903672	positive regulation of sprouting angiogenesis
GO:2000767	positive regulation of cytoplasmic translation

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005791	rough endoplasmic reticulum

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