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Structure of PDB 8zly Chain B Binding Site BS02

Receptor Information >8zly Chain B (length=501) Species: 171101 (Streptococcus pneumoniae R6) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] MNKRVKIVATLGPAVEIRGGKKFGEDGYWGEKLDVEASAKNIAKLIEAGA NTFRFNFSHGDHQEQGERMATVKLAEKIAGKKVGFLLDTKGPEIRTELFE GEAKEYSYKTGEKIRVATKQGIKSTREVIALNVAGALDIYDDVEVGRQVL VDDGKLGLRVVAKDDATREFEVEVENDGIIAKQKGVNIPNTKIPFPALAE RDNDDIRFGLEQGINFIAISFVRTAKDVNEVRAICEETGNGHVQLFAKIE NQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIIKKVNAAGK VVITATNMLETMTEKPRATRSEVSDVFNAVIDGTDATMLSGESANGKYPL ESVTTMATIDKNAQALLNEYGRLDSDSFERNSKTEVMASAVKDATSSMDI KLVVTLTKTGHTARLISKYRPNADILALTFDELTERGLMLNWGVIPMLTD APSSTDDMFEIAERKAVEAGLVESGDDIVIVAGVPVGEAVRTNTMRIRTV R

Ligand information Ligand ID MG InChI InChI=1S/Mg/q+2 InChIKey JLVVSXFLKOJNIY-UHFFFAOYSA-N SMILES Software SMILES ACDLabs 10.04 OpenEye OEToolkits 1.5.0 [Mg+2] CACTVS 3.341 [Mg++] Formula Mg Name MAGNESIUM ION ChEMBL DrugBank DB01378 ZINC PDB chain 8zly Chain B Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 8zly Structural basis of nucleotide selectivity in pyruvate kinase. Resolution 1.89 Å Binding residue (original residue number in PDB) E250 D274 Binding residue (residue number reindexed from 1) E250 D274 Annotation score 1

Gene Ontology Molecular Function GO:0004743 pyruvate kinase activity GO:0005524 ATP binding GO:0016301 kinase activity GO:0046872 metal ion binding

	Biological Process
GO:0006096	glycolytic process
GO:0016310	phosphorylation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

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