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Structure of PDB 3pgy Chain B Binding Site BS02

Receptor Information >3pgy Chain B (length=404) Species: 93062 (Staphylococcus aureus subsp. aureus COL) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] MSYITKQDKVIAEAIEREFQRQNSNIELIASENFVSEAVMEAQGSVLTNK YAEGYPGRRYYGGCEFVDVTESIAIDRAKALFGAEHVNVQPHSGPQANMA VYLVALEMGDTVLGMNLSHAPVNFSGKFYNFVEYGVDKDTERINYDEVRK LALEHKPKLIVAGASAYSRTIDFKKFKEIADEVNAKLMVDMAHIAGLVAA GLHPNPVEYADFVTTTTHKTLRGPRGGMILCKEEYKKDIDKTIFPGIQGG PLEHVIAAKAVAFGEALENNFKTYQQQVVKNAKVLAEALINEGFRIVSGG TDNHLVAVDVKGSIGLTGKEAEETLDSVGITCNKNTIPFDQEKPFVTSGI RLGTPAATTRGFDEKAFEEVAKIISLALKNSKDEEKLQQAKERVAKLTAE YPLY

Ligand information Ligand ID GLY InChI InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) InChIKey DHMQDGOQFOQNFH-UHFFFAOYSA-N SMILES Software SMILES OpenEye OEToolkits 1.5.0 C(C(=O)O)N CACTVS 3.341 NCC(O)=O ACDLabs 10.04 O=C(O)CN Formula C2 H5 N O2 Name GLYCINE ChEMBL CHEMBL773 DrugBank DB00145 ZINC ZINC000004658552 PDB chain 3pgy Chain B Residue 511 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 3pgy Serine hydroxymethyltransferase from Staphylococcus aureus, S95P mutant Resolution 1.92 Å Binding residue (original residue number in PDB) S334 E391 L394 Binding residue (residue number reindexed from 1) S327 E384 L387 Annotation score 5

Enzymatic activity Catalytic site (original residue number in PDB) Y51 E53 D197 T223 K226 R232 Catalytic site (residue number reindexed from 1) Y51 E53 D190 T216 K219 R225 Enzyme Commision number 2.1.2.1: glycine hydroxymethyltransferase.

Gene Ontology Molecular Function GO:0003824 catalytic activity GO:0004372 glycine hydroxymethyltransferase activity GO:0008270 zinc ion binding GO:0016740 transferase activity GO:0030170 pyridoxal phosphate binding GO:0050897 cobalt ion binding GO:0070905 serine binding

	Biological Process
GO:0006545	glycine biosynthetic process
GO:0006565	L-serine catabolic process
GO:0006730	one-carbon metabolic process
GO:0008652	amino acid biosynthetic process
GO:0019264	glycine biosynthetic process from serine
GO:0035999	tetrahydrofolate interconversion
GO:0046653	tetrahydrofolate metabolic process
GO:0046655	folic acid metabolic process

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

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