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Structure of PDB 2ycw Chain B Binding Site BS02

Receptor Information >2ycw Chain B (length=297) Species: 9103 (Meleagris gallopavo) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] AELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITS LACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIETL CVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWW RDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYR EAKEQIRKIDRASKRKRVMLMREHKALKTLGIIMGVFTLCWLPFFLVNIV NVFNRDLVPDWLFVAFNWLGYANSAMNPIIYCRSPDFRKAFKRLLAF

Ligand information Ligand ID CAU InChI InChI=1S/C18H22N2O2/c1-12(2)19-10-13(21)11-22-17-9-5-8-16-18(17)14-6-3-4-7-15(14)20-16/h3-9,12-13,19-21H,10-11H2,1-2H3/t13-/m0/s1 InChIKey BQXQGZPYHWWCEB-ZDUSSCGKSA-N SMILES Software SMILES OpenEye OEToolkits 1.5.0 CC(C)NCC(COc1cccc2c1c3ccccc3[nH]2)O OpenEye OEToolkits 1.5.0 CC(C)NC[C@@H](COc1cccc2c1c3ccccc3[nH]2)O CACTVS 3.341 CC(C)NC[CH](O)COc1cccc2[nH]c3ccccc3c12 CACTVS 3.341 CC(C)NC[C@H](O)COc1cccc2[nH]c3ccccc3c12 ACDLabs 10.04 OC(CNC(C)C)COc3cccc2c3c1c(cccc1)n2 Formula C18 H22 N2 O2 Name (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol; (S)-Carazolol ChEMBL DrugBank DB07543 ZINC ZINC000001567835 PDB chain 2ycw Chain B Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 2ycw Two Distinct Conformations of Helix 6 Observed in Antagonist-Bound Structures of a Beta-1- Adrenergic Receptor. Resolution 3.0 Å Binding residue (original residue number in PDB) W117 D121 V122 F201 F306 F307 N310 N329 Y333 Binding residue (residue number reindexed from 1) W85 D89 V90 F169 F244 F245 N248 N267 Y271 Annotation score 1

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0004930 G protein-coupled receptor activity GO:0004935 adrenergic receptor activity

	Biological Process
GO:0007186	G protein-coupled receptor signaling pathway

	Cellular Component
GO:0016020	membrane

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