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Structure of PDB 2dgk Chain B Binding Site BS02

Receptor Information >2dgk Chain B (length=438) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] SKRFPLHEMRDDVAFQIINDELYLDGNARQNLATFCQTWDDENVHKLMDL SINKNWIDKEEYPQSAAIDLRCVNMVADLWHAPAPKNGQAVGTNTIGSSE ACMLGGMAMKWRWRKRMEAAGKPTDKPNLVCGPVQICWHKFARYWDVELR EIPMRPGQLFMDPKRMIEACDENTIGVVPTFGVTYTGNYEFPQPLHDALD KFQADTGIDIDMHIDAASGGFLAPFVAPDIVWDFRLPRVKSISASGHKFG LAPLGCGWVIWRDEEALPQELVFNVDYLGGQIGTFAINFSRPAGQVIAQY YEFLRLGREGYTKVQNASYQVAAYLADEIAKLGPYEFICTGRPDEGIPAV CFKLKDGEDPGYTLYDLSERLRLRGWQVPAFTLGGEATDIVVMRIMCRRG FEMDFAELLLEDYKASLKYLSDHPKLQGIAQQNSFKHT

Ligand information Ligand ID PLP InChI InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14) InChIKey NGVDGCNFYWLIFO-UHFFFAOYSA-N SMILES Software SMILES CACTVS 3.341 Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O OpenEye OEToolkits 1.5.0 Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O ACDLabs 10.04 O=P(O)(O)OCc1cnc(c(O)c1C=O)C Formula C8 H10 N O6 P Name PYRIDOXAL-5'-PHOSPHATE; VITAMIN B6 Phosphate ChEMBL CHEMBL82202 DrugBank DB00114 ZINC ZINC000001532514 PDB chain 2dgk Chain B Residue 1501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 2dgk Escherichia coli acid resistance: pH-sensing, activation by chloride and autoinhibition in GadB Resolution 1.9 Å Binding residue (original residue number in PDB) S126 S127 Q163 T212 D243 A245 S273 H275 K276 H465 Binding residue (residue number reindexed from 1) S98 S99 Q135 T184 D215 A217 S245 H247 K248 H437 Annotation score 1

Enzymatic activity Enzyme Commision number 4.1.1.15: glutamate decarboxylase.

Gene Ontology Molecular Function GO:0004351 glutamate decarboxylase activity GO:0005515 protein binding GO:0016830 carbon-carbon lyase activity GO:0016831 carboxy-lyase activity GO:0030170 pyridoxal phosphate binding

	Biological Process
GO:0006536	glutamate metabolic process
GO:0006538	glutamate catabolic process
GO:0019752	carboxylic acid metabolic process
GO:0051454	intracellular pH elevation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane

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