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Structure of PDB 1slx Chain B Binding Site BS02

Receptor Information >1slx Chain B (length=219) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] IVGGYTCQENSVPYQVSLNSGYHFCGGSLINDQWVVSAAHCYKSRIQVRL GEHNINVLEGNEQFVNAAKIIKHPNFDRKTLNNDIMLIKLSSPVKVATVA LPSSCAPAGTQCLISGWGHTLSSGVNHPDLLQCLDAPLLPQADCEASYPG KITDNMVCVGFLEGGKDSCQGDSGGPVVCNGELQGIVSWGYGCALPDNPG VYTKVCNYVDWIQDTIAAN

Ligand information Ligand ID ZN InChI InChI=1S/Zn/q+2 InChIKey PTFCDOFLOPIGGS-UHFFFAOYSA-N SMILES Software SMILES CACTVS 3.341 [Zn++] ACDLabs 10.04 OpenEye OEToolkits 1.5.0 [Zn+2] Formula Zn Name ZINC ION ChEMBL CHEMBL1236970 DrugBank DB14532 ZINC PDB chain 1slx Chain B Residue 248 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1slx X-ray structures of a designed binding site in trypsin show metal-dependent geometry. Resolution 2.2 Å Binding residue (original residue number in PDB) H143 H151 Binding residue (residue number reindexed from 1) H119 H127 Annotation score 4

Enzymatic activity Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196 Catalytic site (residue number reindexed from 1) H40 D84 Q170 G171 D172 S173 G174 Enzyme Commision number 3.4.21.4: trypsin.

Gene Ontology Molecular Function GO:0004252 serine-type endopeptidase activity GO:0005509 calcium ion binding GO:0005515 protein binding GO:0008236 serine-type peptidase activity GO:0046872 metal ion binding

	Biological Process
GO:0006508	proteolysis
GO:0007584	response to nutrient
GO:0007586	digestion
GO:0030574	collagen catabolic process

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space

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