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BioLiP

Structure of PDB 8ujt Chain A Binding Site BS02

Receptor Information
>8ujt Chain A (length=424) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVS
YEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVME
IMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLP
QGPQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIERET
GFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSL
GGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIEHD
PVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRND
NDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCNT
SGIQTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ujt Replication Bypass of the N -(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase eta.
Resolution2.31 Å
Binding residue
(original residue number in PDB)		S113 E116 K224 S257 G259 K261 L262 R377 L381 R382
Binding residue
(residue number reindexed from 1)		S112 E115 K216 S249 G251 K253 L254 R369 L373 R374
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:8ujt, PDBe:8ujt, PDBj:8ujt
PDBsum8ujt
PubMed38413007
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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