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●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

Structure of PDB 7tm6 Chain A Binding Site BS02

Receptor Information >7tm6 Chain A (length=426) Species: 1125630 (Klebsiella pneumoniae subsp. pneumoniae HS11286) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] ESLTLQPIARVEGTVNLPGSKSVSNRALLLAALARGTTVLTNLLDSDDVR HMLNALSALGVQYTLSADRTRCEVTGNGGPLRSAAALELFLGNAGTAMRP LAAALCLGSNDIVLTGEPRMKERPIGHLVDALRQGGAQIDCLEQENYPPL RLRGGFQGGNVEVDGSVSSQFLTALLMTAPLAPQDTVIVIKGDLVSKPYI DITLHLMKTFGVEVDNQSYQRFVVRGKQQYQSPGDYLVEGDASSASYFLA AGAIKGGTVKVTGIGRNSVQGDIRFADVLEKMGATVTWGDDFIACTHGEL KAVDMDMNHIPDAAMTIATAALFAQGTTTLRNIYNWRVKETDRLFAMATE LRKVGAEVEEGEDYIRITPPAKLKYAEIGTYNDHRMAMCFSLVALSDTPV TILDPKCTAKTFPDYFEQLARISTLA

Ligand information Ligand ID GPJ InChI InChI=1S/C3H8NO5P/c5-3(6)1-4-2-10(7,8)9/h4H,1-2H2,(H,5,6)(H2,7,8,9)/p+1 InChIKey XDDAORKBJWWYJS-UHFFFAOYSA-O SMILES Software SMILES OpenEye OEToolkits 1.5.0 C(C(=O)O)[NH2+]CP(=O)(O)O CACTVS 3.341 OC(=O)C[NH2+]C[P](O)(O)=O ACDLabs 10.04 O=C(O)C[NH2+]CP(=O)(O)O Formula C3 H9 N O5 P Name GLYPHOSATE ChEMBL DrugBank DB04539 ZINC PDB chain 7tm6 Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 7tm6 Crystal structure of shikimate-3-phosphate and glyphosate bound 3-phosphoshikimate 1-carboxyvinyltransferase from Klebsiella pneumoniae Resolution 1.26 Å Binding residue (original residue number in PDB) K22 G96 R124 Q171 D313 E341 R344 H385 R386 Binding residue (residue number reindexed from 1) K21 G95 R123 Q170 D312 E340 R343 H384 R385 Annotation score 1

Enzymatic activity Enzyme Commision number 2.5.1.19: 3-phosphoshikimate 1-carboxyvinyltransferase.

Gene Ontology Molecular Function GO:0003824 catalytic activity GO:0003866 3-phosphoshikimate 1-carboxyvinyltransferase activity GO:0016740 transferase activity GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups

	Biological Process
GO:0008652	amino acid biosynthetic process
GO:0009073	aromatic amino acid family biosynthetic process
GO:0009423	chorismate biosynthetic process

	Cellular Component
GO:0005737	cytoplasm

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