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BioLiP

Structure of PDB 5x0j Chain A Binding Site BS02

Receptor Information
>5x0j Chain A (length=241) Species: 69014 (Thermococcus kodakarensis KOD1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GVEKVPKYDIPTKKVDYVFIELDKMKPHQQLVQKELEAFIESVTGSGIFW
KPMLLAKVPGEDMYLIVDGHHRWAGLQKLGAKRAPSVILDYFSDDVKVYT
WYPAFKGDLNEVVERLKKEGLEVIEDPEAEEKAERGEIAFALVGEKSFAI
PGGLEEQKKVSKVLDEMSVEGKIELIYYGLKEDAREDMAKGEIDYVFIRK
APTKEEVMELVKRGEVYSPKTTRHVLPFNPDKIDVKLEELF
Ligand information
Ligand IDSEP
InChIInChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1
InChIKeyBZQFBWGGLXLEPQ-REOHCLBHSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=P(O)(O)OCC(C(=O)O)N
OpenEye OEToolkits 1.5.0C(C(C(=O)O)N)OP(=O)(O)O
CACTVS 3.341N[CH](CO[P](O)(O)=O)C(O)=O
CACTVS 3.341N[C@@H](CO[P](O)(O)=O)C(O)=O
OpenEye OEToolkits 1.5.0C([C@@H](C(=O)O)N)OP(=O)(O)O
FormulaC3 H8 N O6 P
NamePHOSPHOSERINE;
PHOSPHONOSERINE
ChEMBLCHEMBL284377
DrugBankDB04522
ZINCZINC000003869280
PDB chain5x0j Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5x0j Structural Study on the Reaction Mechanism of a Free Serine Kinase Involved in Cysteine Biosynthesis
Resolution1.43 Å
Binding residue
(original residue number in PDB)		Q30 V68 D69 H71 H72 W102 K221 T223 R224 H225
Binding residue
(residue number reindexed from 1)		Q29 V67 D68 H70 H71 W101 K220 T222 R223 H224
Annotation score5
Enzymatic activity
Enzyme Commision number 2.7.1.226: L-serine kinase (ADP).
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0016310 phosphorylation
GO:0019344 cysteine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5x0j, PDBe:5x0j, PDBj:5x0j
PDBsum5x0j
PubMed28358477
UniProtQ5JD03|SERK_THEKO L-serine kinase SerK (Gene Name=serK)

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